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KMID : 0123420050100060963
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Korean Journal of Community Nutrition
2005 Volume.10 No. 6 p.963 ~ p.970
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Plasma Total Homocysteine, Folate and Vitamin B_{12} Concentrations in Patients with Coronary Stenosis
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Abstract
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Recently elevated plasma homocysteine concentration is considered an independent risk factor for atherosclerosis and thrombosis with coronary artery disease. Folate and vitamin B_{12} are cofactors and closely related with metabolism of homocysteine. The purpose of this study is to evaluate the correlation between homocysteine and folate and vitamin B_{12} in patients with ischemic heart disease. Twenty-six patients, in whom coronary angiographic finding revealed more than 50% of stenosis at least in one coronary vessel were enrolled as the patient group, and thirty subjects, in whom angiographic finding revealed in not significant stenosis, but complained of chest pain, were selected as the control group. Fasting venous blood was obtained and measured the concentration of plasma total homocysteine, folate and vitamin B_{12} by high performance liquid chromatography and fluorescence detection method. We examined the correlation between homocysteine and folate and/or vitamin B_{12} in the control group and the patient group, respectively. Compared with the control group, the patient group had relatively higher plasma total homocysteine concentration (10.7pm4.2 vs 9.6pm3.5 umol/L), but showed no significant difference. Folate and vitamin B_{12} concentration are low in the patient group, but showed no significant difference between patient and control group. Plasma total homocysteine concentration showed negative correlation with folate and vitamin B_{12} in both the control group and the patient group, and showed significantly negative correlation in patient group {r = -0.550 (p < 0.01) vs r = -0.609 (p < 0.01)}. We knew that the plasma total homocysteine concentration were relatively elevated in patient group compared with the control group. Because plasma total homocysteine concentrations are closely negative correlated with folate and vitamin B_{12} in the patient group, folate and vitamin B_{12} supplement can lower the mortality and morbidity of ischemic heart disease.
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KEYWORD
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